IVF success could double with new way of detecting faulty egg cells

In a study that could change the prospects for the 1 in 15 infertile couples worldwide, researchers in China and the US show how their way of finding genetic defects in egg cells could double the success rate of the reproductive treatment in vitro fertilization. The new method, based on whole-genome sequencing of individual egg cells, could lead to an accurate, safe and cheap way to select genetically normal embryos for in vitro fertilization (IVF), thus

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ww.conceiveplus.com/pregnancy-tips/">increasing the chances of producing a healthy baby. As well as looking for DNA sequence variations associated with known genetic disorders, the new approach detects chromosome abnormalities. Study author Jie Qiao, department director and professor of Gynecology and Obstetrics, Peking University, 3rd Hospital, says: "In this way, we kill two birds with one stone: one set of deep sequencing analysis to avoid two types of genetic problems." "Theoretically, if this works perfectly, we will be able to double the success rate of test tube baby technology from 30% to 60% or even more." The researchers write about their work in a recent online issue of the journal Cell.

Frequently Asked Questions

What is whole-genome sequencing for IVF and how could it double success rates?

Whole-genome sequencing is a new technique that analyses the complete DNA of individual egg cells to detect both genetic disorders and chromosome abnormalities in one test. Researchers suggest this could potentially increase IVF success rates from around 30% to 60% by helping embryologists select the healthiest embryos for transfer. This dual-screening approach is still being developed but offers promising prospects for couples undergoing fertility treatment.

Is genetic testing of embryos available on the NHS?

Pre-implantation genetic testing (PGT) is currently available on the NHS, but only for couples who have a known risk of passing on a serious genetic condition. According to NICE guidelines, eligibility depends on your specific circumstances and local CCG funding criteria. If you're interested in genetic screening during IVF, speak to your fertility consultant about whether you qualify for NHS-funded testing or would need to pay privately.

How long are NHS IVF waiting times in the UK?

NHS IVF waiting times vary significantly depending on your local Integrated Care Board (formerly CCG), but typically range from several months to over two years. With 1 in 7 UK couples experiencing fertility issues, demand for treatment is high. You can ask your GP or fertility clinic about current waiting times in your area and whether you meet the NICE eligibility criteria for NHS-funded cycles.

What genetic tests are currently used during IVF in the UK?

UK fertility clinics regulated by the HFEA currently offer pre-implantation genetic testing for monogenic disorders (PGT-M) and chromosomal abnormalities (PGT-A). PGT-A, which screens embryos for chromosome problems, is widely available privately but the HFEA notes that evidence for its effectiveness is still being evaluated. The new whole-genome sequencing method discussed in this research could potentially offer more comprehensive screening in the future.

Will this new egg cell testing be available at UK fertility clinics soon?

While this research from China and the US is promising, new fertility treatments typically take several years to become available in UK clinics. Any new genetic screening technique would need to be approved and licensed by the HFEA before being offered to patients. It's worth keeping an eye on developments, but current options like PGT-A remain the standard for embryo screening in the UK.

How much does genetic testing during IVF cost privately in the UK?

Private genetic testing during IVF typically costs between £2,000 and £4,000 on top of standard IVF fees, depending on the clinic and type of testing required. This can add significantly to the overall cost of a cycle, which already averages £3,000-£5,000 according to the HFEA. If the new whole-genome sequencing method proves to be cheaper as researchers suggest, it could make comprehensive genetic screening more accessible for couples trying to conceive.

Can I request specific genetic tests during my NHS fertility treatment?

NHS-funded genetic testing during IVF is generally only offered when there's a known hereditary condition in your family that could affect your baby. Your fertility specialist will discuss your options based on your medical history and NICE guidelines. If you're interested in additional screening not covered by the NHS, many clinics offer private add-on services, though the HFEA recommends discussing the evidence for these tests with your consultant first.